Sodium Hydroxide → HCID 24753031, compound

Participants

Reaction Steps

A solution of ethyl 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[2-(2-pyridylamino)ethylamino]quinoline-2-carboxylate (317 mg, 0.715 mmol) and 1M aq. NaOH (1.4 mL) in EtOH (7 mL) was stirred at room temperature for over night. The solvent was removed and the residue was dissolved in water. The solution was acidified to pH 7 with 2M HCl and the resulting precipitate was removed by filtration, washed with CH3CN, and dried to yield 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[2-(2-pyridylamino)ethylamino]quinoline-2-carboxylic acid (246 mg, 83%) as a yellow solid.

Provenance & Evidence