反应详情

A solution of ethyl 5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-2-methyl-4-oxoquinoline-3-carboxylate (187 mg, 0.531 mmol) and 1M aq. NaOH (1 mL) in EtOH (3 mL) was stirred at 50° C. for 1 h. After the reaction mixture was concentrated in vacuo, the residue was dissolved in water and 2M HCl was added to pH<3. The resulting precipitate was collected by filtration in vacuo, washed with water and dried to yield 5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-2-methyl-4-oxoquinoline-3-carboxylic acid (161 mg, 93%) as a pale yellow solid.

1. concentrationAfter the reaction mixture was concentrated in vacuo
2. dissolutionthe residue was dissolved in water
3. addition2M HCl was added to pH<3
4. filtrationThe resulting precipitate was collected by filtration in vacuo
5. washwashed with water
6. customdried