Hydrochloric Acid → HCID 59002917, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 5-amino-6-chloro-1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (236 mg, 0.665 mmol) and 1M aq. NaOH (1.06 mL, 1.06 mmol) in EtOH (3 mL) was stirred at 50° C. for 1 h. To the reaction mixture, ice-water and 2M HCl was added to pH<3 and the resulting precipitate was collected by filtration in vacuo, washed with water and dried to yield 5-amino-6-chloro-1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid (204 mg, 94%) as a pale yellow solid.

Provenance & Evidence