Isopropyl iodide → HCID 59002824, compound

Participants

Reaction Steps

A solution of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxoquinoline-3-carboxylate (1.10 g, 3.56 mmol), 2-Iodopropane (0.534 mL, 5.34 mmol) and K2CO3 (738 mg, 5.34 mmol) in DMF (10 mL) was stirred at room temperature for 1 h and at 70° C. for 3 h. After cooled to room temperature, the reaction mixture was poured into ice-water and the resulting precipitate was collected by filtration, washed with water and dried to yield ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-isopropoxy-4-oxoquinoline-3-carboxylate (611 mg, 49%) as a colorless solid.

Provenance & Evidence