Potassium Nitrate → HCID 59002972, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-isopropoxy-4-oxoquinoline-3-carboxylate (600 mg, 1.71 mmol) in concentrated H2SO4 (5 mL) was treated portion wise with solid KNO3 (242 mg, 2.39 mmol) at 0° C. After stirred at 0° C. for 30 min and at room temperature for 1 h, the reaction mixture was poured into ice-water and the resulting precipitate was collected by filtration, washed with water and dried to yield ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-5-nitro-4-oxoquinoline-3-carboxylate (393 mg, 65%) as a pale brown solid.

Provenance & Evidence