Isopropyl iodide → HCID 59002975, compound

Participants

Reaction Steps

A solution of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-5-nitro-4-oxoquinoline-3-carboxylate (393 mg, 1.11 mmol), 2-Iodopropane (0.167 mL, 1.67 mmol) and K2CO3 (231 mg, 1.67 mmol) in DMF (5 mL) was stirred at 80° C. for 5 h. After the reaction mixture was poured into ice-water, the crude product was extracted with CH2Cl2, washed with 1M HCl, saturated aq. NaHCO3 and brine, dried over MgSO4 and the solvent was removed in vacuo. The crude product washed with hot EtOH and dried to yield ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-isopropoxy-5-nitro-4-oxoquinoline-3-carboxylate (237 mg, 54%) as a pale yellow solid.

Provenance & Evidence