HCID 59002855, compound → HCID 59002956, compound

Participants

Reaction Steps

To a suspension of ethyl 5-benzylamino-6,7-difluoro-1,4-dihydro-4-oxo-1-(2-phenylethyl)-3-quinolinecarboxylate (700 mg, 1.51 mmol) in a mixture of EtOH (2 mL) and AcOH (2 mL), was added 10% Pd—C (70.0 mg), the whole mixture was stirred at room temperature for 4 h under H2 atmosphere (1 atm). After insoluble materials were filtered off, the filtrate was concentrated in vacuo. To a solution of the residue in AcOH (2 mL), a suspension of 10% Pd—C (70 mg) in AcOH (2 mL) was added, the whole mixture was stirred at room temperature for 4 h under H2 atmosphere (1 atm). After insoluble materials were filtered off and washed with DMF, the combined filtrate and washing was concentrated in vacuo. Trituration of the residue with EtOH gave ethyl 5-amino-6,7-difluoro-1,4-dihydro-4-oxo-1-(2-phenylethyl)-3-quinolinecarboxylate (499 mg, 89%) as pale brown powder.

Provenance & Evidence