HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-(5-Nitrothiazol-2-yl)phenyl)morpholine → 2-(4-Morpholinophenyl)thiazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-(5-Nitrothiazol-2-yl)phenyl)morpholine | HCID 90022660 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Morpholinophenyl)thiazol-5-amine | HCID 90022908 | — |
Reaction Steps
To a solution of 4-(4-(5-nitrothiazol-2-yl)phenyl)morpholine (0.70 g, 2.44 mmol) in CH2Cl2 (20 mL) was added Pd/C (70 mg). The reaction mixture was stirred at rt under H2 overnight, and filtered. The filtrate was concentrated in vacuo to give the title compound as an offwhite solid (0.20 g, 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-27f6e5cccbac4547b2bdd574a7edf9c1 |
| Source note | uspto-grants-2016_09 |