Sodium Hydroxide → 3-(3-{5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)propanoic acid

HRID 561227Notes

Reaction equation

HRID 561227 reaction equation
[Br:1][C:2]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[S:15][C:14]([C:16]3[N:20]=[C:19]([CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[O:18][N:17]=3)=[N:13][N:12]=2)[CH2:7][CH2:6]1.[OH-].[Na+]>>[Br:1][C:2]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[S:15][C:14]([C:16]3[N:20]=[C:19]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[O:18][N:17]=3)=[N:13][N:12]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 66696811Ethyl 3-(3-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)propanoate

Product 1

HCID 597381823-(3-{5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)propanoic acid

Procedure

The title compound was prepared in a similar manner as described in Example 7 (step 5) from ethyl 3-(3-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)propanoate and 1N NaOH.

Sources & evidence

ORD record
ord-df828ef3337248d68ca043f02aebd81d
Source dataset
uspto-grants-2011_11
Patent number
US08063224B2

Reaction notes

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