Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(5-Bromo-2-chlorophenoxy)piperidine

HRID 561228Notes

Reaction equation

HRID 561228 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[Br:15][C:16]1[CH:17]=[CH:18][C:19]([Cl:23])=[C:20](O)[CH:21]=1>>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:23])=[C:18]([CH:17]=1)[O:1][CH:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 8203925-Bromo-2-chlorophenol

Product 1

HCID 640112854-(5-Bromo-2-chlorophenoxy)piperidine

Procedure

The title compound was prepared in a similar manner as described for Intermediate 1 from tert-butyl 4-hydroxypiperidine-1-carboxylate and 5-bromo-2-chlorophenol.

Sources & evidence

ORD record
ord-af1026df5b1a43b68565c1083734c07e
Source dataset
uspto-grants-2011_11
Patent number
US08063224B2

Reaction notes

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