[(4R)-2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl]acetyl fluoride → (5R)-5-[(3-{5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)methyl]-2,2-dimethyl-1,3-dioxolan-4-one

Participants

Reaction Steps

The title compound was prepared in a similar manner as described for Example 13, step 2 from 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-N′-hydroxy-1,3,4-thiadiazole-2-carboximidamide and [(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetyl fluoride.

Provenance & Evidence