HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Malic Acid → (2S)-3-(3-{5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)-2-hydroxypropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Malic Acid | HCID 222656 | — |
| Reactant | 5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-N'-hydroxy-1,3,4-thiadiazole-2-carboximidamide | HCID 136360151 | — |
| Product | (2S)-3-(3-{5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1,2,4-oxadiazol-5-yl)-2-hydroxypropanoic acid | HCID 59738194 | — |
Reaction Steps
The title compound was prepared in a similar manner as described for Example 16 from 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-N′-hydroxy-1,3,4-thiadiazole-2-carboximidamide and (S)-(−)-malic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063224B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-97355bc80a274058845262eb47c88613 |
| Source note | uspto-grants-2011_11 |