Toluene → HCID 86620467, compound

Participants

Reaction Steps

To a solution of N-(trifluoroacetyl)-L-aspartic acid α-ethyl ester (3 g, 11.7 mmol) in dry toluene (15 mL) was added SOCl2 (3 mL). After stirring at reflux for 1 h, the solution was cooled to rt. The mixture was filtered and the solid was washed with cold toluene. The solid was dried to afford the title compound. 1H NMR (400 MHz, CDCl3): δ4.71-4.75 (m, 1H), 4.28-2.36 (m, 2H), 3.64-3.70 (m, 1H), 3.56-3.61 (m, 1H), 1.31 (t, J=6 Hz, 3H).

Provenance & Evidence