HCID 25020358, compound → HCID 25020124, compound

Participants

Reaction Steps

3-(4-Chlorophenyl)-1-(1-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-1H-pyrazol-4-yl)-1H-imidazol-2(3H)-one obtained in Step 5 (0.026 g, 0.051 mmol) was dissolved in acetic acid (1 mL), and 5% palladium on charcoal (5% Pd/C, 0.01 g) was added thereto, and the resulting mixture was stirred for 3 hours under a hydrogen atmosphere. The reaction mixture was filtered through celite and the filtrate was concentrated by evaporation under a reduced pressure to obtain the title compound (0.016 g, yield 62%).

Provenance & Evidence