Calcium Carbonate → HCID 25020125, compound

Participants

Reaction Steps

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyl oxiran-2-yl)methyl)-1H-1,2,4-triazol obtained in step 3 (55.9 mg) was suspended in N,N-dimethylformamide (1.6 mL), and calcium carbonate (41.9 mg) and 4-((E)-2-(1H-pyrazol-4-yl)vinyl)benzonitrile (39.5 mg) were added thereto. The mixture was stirred at room temperature for 20 minutes under an argon atmosphere, and reacted by microwave irradiation at 180° C. for 15 minutes. After completion of the reaction, the resulting mixture was extracted with ethyl acetate (10 mL) and the extract was washed successively with saturated amoniumchloride (10 mL) and brine (10 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated by evaporation under a reduced pressure. The resulting residue was purified by silica gel chromatography to obtain the title compound (0.039 g, yield 43.5%).

Provenance & Evidence