HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → (3-Bromo-2-methoxyphenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(Azidomethyl)-3-bromo-2-methoxybenzene | HCID 59778681 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3-Bromo-2-methoxyphenyl)methanamine | HCID 57813384 | — |
Reaction Steps
1.1 g of potassium hydroxide (KOH) and 5.8 g of triphenyl phosphine (Ph3P) were added to a solution of 1-azidomethyl-3-bromo-2-methoxy-benzene 7 in 100 mL of THF and 10 mL of water. The mixture was stirred overnight at room temperature. The mixture was quenched with aqueous concentrated hydrochloride. After standard acid/base aqueous work up, 3.9 g of crude 3-bromo-2-methoxy-benzylamine 8 was obtained (after two steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063231B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6bc45ea5a649452e94a45736d7546d0f |
| Source note | uspto-grants-2011_11 |