Pyrazole → 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole

Participants

Reaction Conditions

Reaction Steps

To a solution of 1,2-difluoro-4-nitrobenzene (3.18 g, 20 mmol) in DMSO (35 mL) were added K2CO3 (6.08 g, 44 mmol) and pyrazole (1.50 g, 22 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL) and filtered. The filtrate was extracted with DCM (50 mL×3), the combined organic phases were concentrated in vacuo. The crude product was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=1:1) to give the title compound as a yellow solid (3.31 g, 80%).

Provenance & Evidence