反应详情

To a solution of 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole (3.31 g, 16 mmol) in CH2Cl2 (60 mL) was added catalyst Pd/C (0.33 g). The reaction mixture was stirred at rt under H2 overnight, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=1:1) to give the title compound as a white solid (1.30 g, 46%).

1. filtrationfiltered
2. concentrationThe filtrate was concentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=1:1)