HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 58392224, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | tert-Butyl 7-(bromomethyl)-1H-indole-1-carboxylate | HCID 21874701 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58392224 | HCID 58392224 | — |
Reaction Steps
160 mg (516 μmmol) of the compound from Example 6A and 36.2 mg (516 μmol) of sodium methanethiolate were stirred in 5 ml of dimethylformamide at RT for three days. Water was then added, and the mixture was extracted with ethyl acetate. The organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate gradient) to result in 64 mg (45% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c05c3154dfa5483b9f7922ec019d8c5b |
| Source note | uspto-grants-2011_11 |