proline dl-form → HCID 59293936, compound

Participants

Reaction Steps

268 mg (1.54 mmol) of 4-(trifluoromethyl)benzaldehyde, 222 mg (1.54 mmol) of Meldrum's acid and 8.4 mg (0.07 mmol) of D,L-proline were added to a solution of 260 mg (1.47 mmol) of the compound from Example 8A in 12 ml of acetonitrile. The reaction mixture was stirred at RT overnight. It was concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid) to result in 504 mg (72% of theory) of the title compound.

Provenance & Evidence