HuagongsheHuagongshe Chemistry Print Report · For research reference only
proline dl-form → HCID 58392340, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | proline dl-form | HCID 614 | — |
| Reactant | 2,4-Dichlorobenzaldehyde | HCID 13404 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 5-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392227 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58392340 | HCID 58392340 | — |
Reaction Steps
0.81 g (4.60 mmol) of 2,4-dichlorobenzaldehyde, 0.66 g (4.60 mmol) of Meldrum's acid and 25 mg (0.22 mmol) of D,L-proline were added to a solution of 0.95 g (4.38 mmol) of the compound from Example 11A in 36 ml of acetonitrile. The reaction mixture was stirred at RT overnight. It was concentrated to result in 3.10 g (97% of theory) of the title compound with a purity of 68% which were reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0062b61931c24b918ff9b8e86099ed4c |
| Source note | uspto-grants-2011_11 |