HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-[1-(4-chlorophenyl)-3-ethoxy-3-oxopropyl]-7-[(methylsulfanyl)methyl]-1H-indole-1-carboxylate → tert-Butyl 3-[1-(4-chlorophenyl)-3-ethoxy-2-methyl-3-oxopropyl]-7-[(methylsulfanyl)methyl]-1H-indole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-[1-(4-chlorophenyl)-3-ethoxy-3-oxopropyl]-7-[(methylsulfanyl)methyl]-1H-indole-1-carboxylate | HCID 58392383 | — |
| Reactant | tert-Butyl 3-{3-ethoxy-2-methyl-3-oxo-1-[4-(trifluoromethyl)phenyl]propyl}-7-[(methylsulfanyl)methyl]-1H-indole-1-carboxylate | HCID 58392421 | — |
| Product | tert-Butyl 3-[1-(4-chlorophenyl)-3-ethoxy-2-methyl-3-oxopropyl]-7-[(methylsulfanyl)methyl]-1H-indole-1-carboxylate | HCID 58392107 | — |
Reaction Steps
The title compound was prepared starting from 1.62 g (91% purity, 3.01 mmol) of the compound from Example 30A in analogy to the synthesis of the compound from Example 27A. 0.89 g (59% of theory) of the title compound was obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2346f0fd7a3d457bb038bb5afcec3b7b |
| Source note | uspto-grants-2011_11 |