反应详情

2 mg (0.03 mmol) of copper powder were added to 1.38 g (3.00 mmol) of the compound from Example 14A in 15 ml of pyridine and 5 ml of ethanol. The reaction mixture was heated under reflux for 1 h. It was concentrated, and the residue was taken up in ethyl acetate, washed with 1N hydrochloric acid, dried over magnesium sulfate, filtered through silica gel and concentrated. 1.13 g of the target compound with a purity of 84% (78% of theory) were obtained.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 1 h
3. concentrationIt was concentrated
4. washwashed with 1N hydrochloric acid
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered through silica gel
7. concentrationconcentrated