反应详情

2.8 mg (0.05 mmol) of copper powder were added to 3.10 g of the compound from Example 18A with a purity of 68% (4.23 mmol) in 34 ml of pyridine and 8 ml of ethanol. The reaction mixture was heated under reflux for 1 h. It was concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient) to result in 1.52 g (82% of theory) of the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 1 h
3. concentrationIt was concentrated
4. customthe crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)