反应详情

2.0 mg (0.03 mmol) of copper powder were added to 2.21 g (3.08 mmol) of the compound from Example 19A with a purity of 64% in 23 ml of pyridine and 6 ml of ethanol. The reaction mixture was heated under reflux for 1 h. It was concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient) to result in 1.29 g (82% of theory) of the title compound with a purity of 79%.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 1 h
3. concentrationIt was concentrated
4. customthe crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)