Ethyl 3-(4-chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate → Ethyl 3-(1-benzothiophen-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate

HRID 561408Notes

Reaction equation

HRID 561408 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:21]3[C:29]4[C:24](=[C:25]([CH2:30][S:31][CH3:32])[CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH:11]3C(=O)O[C:14](C)([CH3:18])[O:13][C:12]3=[O:20])=[CH:9][C:4]=2[CH:3]=[CH:2]1.ClC1C=CC(C(C2C3C(=C(CSC)C(F)=CC=3)NC=2)CC(OCC)=O)=CC=1>>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:21]3[C:29]4[C:24](=[C:25]([CH2:30][S:31][CH3:32])[CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH2:11][C:12]([O:13][CH2:14][CH3:18])=[O:20])=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 58392255Ethyl 3-(4-chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoateHCID 583922775-[(1-Benzothiophen-5-yl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 58392303Ethyl 3-(1-benzothiophen-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate

Procedure

The title compound was prepared starting from 1.73 g (71% purity, 3.72 mmol) of the compound from Example 23A in analogy to the synthesis of the compound from Example 47A. 1.23 g (81% of theory) of the title compound were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-598af0dd01204ca3ab284ec9ca56c555
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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