HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzaldehyde → (4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 2-Bromo-5-chlorotoluene | HCID 84476 | — |
| Reactant | alpha-(4-Fluorophenyl)-4-(trifluoromethyl)benzenemethanol | HCID 579773 | — |
| Product | (4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol | HCID 58392095 | — |
Reaction Steps
The title compound was prepared starting from 1.00 g (4.87 mmol) of 2-bromo-5-chlorotoluene and 0.72 g (5.84 mmol) of 4-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 80A. 0.64 g (52% of theory) of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-bef130b1c5ae4c6dac3ab49c24c06c69 |
| Source note | uspto-grants-2011_11 |