反应详情

2.1 mg (34 μmol) of copper powder were added to a solution of 2.48 g of the compound from Example 92A in 28 ml of pyridine and 8 ml of ethanol. The reaction mixture was heated under reflux for 1 h. It was concentrated, and the crude product was purified by flash chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate gradient) to result in 0.69 g of the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 1 h
3. concentrationIt was concentrated
4. customthe crude product was purified by flash chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate gradient)