反应详情

2.8 mg (45 μmol) of copper powder were added to a solution of 3.64 g (approx. 5.12 mmol, 72% purity) of the compound from Example 93A in 41 ml of pyridine and 10 ml of ethanol. The reaction mixture was heated under reflux overnight. It was concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient) to result in 1.34 g (57% of theory) of the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux overnight
3. concentrationIt was concentrated
4. customthe crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)