反应详情

温度

80 °C

700 mg (2.61 mmol) of the compound from Example 90A and 576 mg (2.61 mmol) of indium(III) chloride were added to 462 mg (2.61 mmol) of the compound from Example 8A in 11 ml of toluene. The reaction mixture was stirred at 80° C. for 5 h. After cooling to RT, the solid was filtered off through silica gel, and the solvents were removed in a rotary evaporator. Purification of the crude product by preparative HPLC (mobile phase: acetonitrile/water gradient) resulted in 69 mg (6% of theory) of the title compound.

1. temperatureAfter cooling to RT
2. filtrationthe solid was filtered off through silica gel
3. customthe solvents were removed in a rotary evaporator
4. customPurification of the crude product by preparative HPLC (mobile phase: acetonitrile/water gradient)