HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- | HCID 23255822 | — |
Reaction Steps
The title compound was prepared starting from 1.50 g (7.97 mmol) of 4′-(trifluoromethyl)acetophenone and 31.9 ml (15.95 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.27 g (69% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-66427df2611d405f8128625bf62943a8 |
| Source note | uspto-grants-2011_11 |