HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Reactant | 1-(3-Fluoro-4-methoxyphenyl)ethan-1-one | HCID 96828 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethanol | HCID 58392223 | — |
Reaction Steps
The title compound was prepared starting from 1.50 g (8.92 mmol) of 3-fluoro-4-methoxyacetophenone and 35.7 ml (17.8 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.38 g (74% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-76d9f13cfe57458898b4fedd9bb1be65 |
| Source note | uspto-grants-2011_11 |