4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → alpha-Cyclopropyl-2,3-dihydro-alpha-methyl-1,4-benZodioxin-6-methanol

Participants

Reaction Steps

The title compound was prepared starting from 1.50 g (8.42 mmol) of 1,4-benzodioxan-6-yl methyl ketone and 33.7 ml (16.84 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.12 g (59% of theory) of the title compound were obtained.

Provenance & Evidence