HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Reactant | 5-Acetyl-2,2-difluoro-1,3-benzodioxole | HCID 26985218 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethanol | HCID 58392505 | — |
Reaction Steps
The title compound was prepared starting from 0.75 g (3.75 mmol) of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethanone and 15.0 ml (7.50 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 0.67 g (74% of theory) of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ee4b4eddab094b08a50098e86105b3cc |
| Source note | uspto-grants-2011_11 |