HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Chloropropiophenone → 1-Cyclopropyl-1-(4-chlorophenyl)propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Chloropropiophenone | HCID 22697 | — |
| Reactant | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Cyclopropyl-1-(4-chlorophenyl)propanol | HCID 58392507 | — |
Reaction Steps
The title compound was prepared starting from 1.50 g (8.90 mmol) of 1-(4-chlorophenyl)propan-1-one and 35.6 ml (17.79 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.42 g (76% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6003ee12bd584f2b9382fe164d648bb4 |
| Source note | uspto-grants-2011_11 |