HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → HCID 58392327, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| Reactant | Methyl 4-chloro-2-fluorobenzoate | HCID 2759832 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58392327 | HCID 58392327 | — |
Reaction Steps
The title compound was prepared starting from 2.00 g (10.61 mmol) of methyl 4-chloro-2-fluorobenzoate and 31.8 ml (31.82 mmol) of a 1N solution of ethylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.27 g (55% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-15b46233795040f89ad33a2c137cd673 |
| Source note | uspto-grants-2011_11 |