HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-5-formylbenzodioxole → Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-5-formylbenzodioxole | HCID 2736973 | — |
| Reactant | (4-Chloro-2,6-difluorophenyl)(cyclopropyl)methanol | HCID 58392245 | — |
| Reactant | HCID 178418630 | HCID 178418630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methanol | HCID 58392116 | — |
Reaction Steps
The title compound was prepared starting from 3.50 g (18.81 mmol) of 2,2-difluoro-5-formylbenzodioxolane and 56.4 ml (28.21 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 156A. 1.59 (37% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-509e347e6f664567bf31646d9940493f |
| Source note | uspto-grants-2011_11 |