HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-fluorotoluene → (4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-fluorotoluene | HCID 96743 | — |
| Reactant | 4-Chloro-2-fluorobenzaldehyde | HCID 2724908 | — |
| Reactant | (4-Chlorophenyl)(4-methoxyphenyl)methanol | HCID 2757631 | — |
| Product | (4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methanol | HCID 58392534 | — |
Reaction Steps
The title compound was prepared starting from 5.00 g (26.45 mmol) of 2-bromo-5-fluorotoluene and 5.03 g (31.74 mmol) of 4-chloro-2-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. A difference was that the crude product was purified twice by preparative HPLC. 4.84 g (65% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-75ebf9905fdc4544a7bf8ef51b8318fe |
| Source note | uspto-grants-2011_11 |