HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-fluorobenzene → 1-(4-Chloro-2-fluorophenyl)-1-(4-fluorophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | (4-Chloro-3-fluorophenyl)(4-fluorophenyl)methanol | HCID 2757452 | — |
| Reactant | 1-(4-Chloro-2-fluorophenyl)ethan-1-one | HCID 15030552 | — |
| Product | 1-(4-Chloro-2-fluorophenyl)-1-(4-fluorophenyl)ethanol | HCID 58392419 | — |
Reaction Steps
The title compound was prepared starting from 4.22 g (24.14 mmol) of 4-bromofluorobenzene and 5.00 g (28.97 mmol) of 4-chloro-2-fluoroacetophenone in analogy to the synthesis of the compound from Example 176A. A difference was that the crude product was purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 9/1). 5.23 g (73% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-658db080808547a094883e66a03bce51 |
| Source note | uspto-grants-2011_11 |