HCID 58392169, compound → HCID 58392460, compound

HRID 561511Notes

Reaction equation

HRID 561511 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][C:12]1([F:15])[F:14])=[O:10].FC1(F)CC1C(C1C=CC(C(F)(F)F)=CC=1)O>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH:11]1[CH2:13][C:12]1([F:15])[F:14])[OH:10]

Participants

3

Reactant 2

HCID 58392169HCID 58392169, compoundHCID 58392207HCID 58392207, compound

Product 1

HCID 58392460HCID 58392460, compound

Procedure

The title compound was prepared starting from 9.00 g (35.8 mmol) of the compound from Example 189A in analogy to the synthesis of the compound from Example 190A. 7.30 g (80% of theory) of diastereomer 1 and 1.10 g (12% of theory) of diastereomer 2 of the title compound were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-f5f2d781e8494cdd99a9f073be204c74
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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