Hydrochloric Acid → HCID 58392164, compound

Participants

Reaction Steps

A solution of 585 mg (1.52 mmol) of the compound from Example 43A in 15 ml of tetrahydrofuran was added dropwise to 5.3 ml (5.31 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 30 ml of tetrahydrofuran at RT under argon. The mixture was stirred at RT for 15 min and then, while cooling in ice, 1N hydrochloric acid was added. The mixture was extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate, filtered and concentrated. The crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid) to result in 369 mg (71% of theory) of the title compound.

Provenance & Evidence