Hydrochloric Acid → HCID 58392440, compound

Participants

Reaction Steps

A solution of 600 mg (1.49 mmol) of the compound from Example 45A in 15 ml of tetrahydrofuran was added dropwise to 5.2 ml (5.2 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 30 ml of tetrahydrofuran at RT under argon. Stirring at RT for 15 min was followed by addition, while cooling in ice, of 1N hydrochloric acid, extraction with ethyl acetate, drying of the organic phase over magnesium sulfate, filtration and concentration. 486 mg (90% of theory) of the title compound were obtained.

Provenance & Evidence