Hydrochloric Acid → HCID 58392477, compound

Participants

Reaction Steps

A solution of 420 mg (1.05 mmol) of the compound from Example 46A in 10 ml of tetrahydrofuran was added dropwise to 3.7 ml (3.7 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran under argon in 20 ml of tetrahydrofuran at RT. The mixture was stirred at RT for 15 min and then, while cooling in ice, 1N hydrochloric acid was added. The mixture was extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid). 243 mg (65% of theory) of the target compound were obtained.

Provenance & Evidence