1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol → 1-(4-Amino-2-fluorophenyl)piperidin-4-ol

Participants

Reaction Steps

To a solution of 1-(2-fluoro-4-nitrophenyl)piperidin-4-ol (2.67 g, 11 mmol) in MeOH (100 mL) was added catalyst Pd/C (1.00 g). The reaction mixture was stirred at rt under H2 for 6 h, then filtered. The filtrate was concentrated in vacuo to give the crude product (2.50 g) for the next step without further purification.

Provenance & Evidence