HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate → 3-(4-Chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate | HCID 58392240 | — |
| Reactant | 3-(2-Bromo-1,3-thiazol-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392463 | — |
| Product | 3-(4-Chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392174 | — |
Reaction Steps
The title compound was prepared starting from 395 mg (0.98 mmol) of the compound from Example 32A in analogy to the synthesis of the compound from Example 19. 222 mg (63% of theory) of the title compound were obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-aa5b0d3e126244ab96a4172da7c67bbd |
| Source note | uspto-grants-2011_11 |