Potassium Cyanide → HCID 58392400, compound

Participants

Reaction Conditions

Reaction Steps

572 mg (8.78 mmol) of potassium cyanide were added to 1.94 g (4.39 mmol) of the compound from Example 54A in 26 ml of DMF. The mixture was stirred at 80° C. for 2 h and then concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid) to result in 1.30 g (79% of theory) of the title compound.

Provenance & Evidence