HCID 58392219, compound → HCID 58392229, compound

HRID 561555Notes

Reaction equation

HRID 561555 reaction equation
CS(O[CH2:6][CH2:7][CH:8]([C:19]1[C:27]2[C:22](=[C:23]([CH2:29][S:30][CH3:31])[C:24]([F:28])=[CH:25][CH:26]=2)[NH:21][CH:20]=1)[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)(=O)=O.ClC1C=CC(C(C2C3C(=C(CSC)C(F)=CC=3)NC=2)CC[C:42]#[N:43])=CC=1>>[F:28][C:24]1[C:23]([CH2:29][S:30][CH3:31])=[C:22]2[C:27]([C:19]([CH:8]([C:9]3[CH:10]=[CH:11][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:13][CH:14]=3)[CH2:7][CH2:6][C:42]#[N:43])=[CH:20][NH:21]2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 58392219HCID 58392219, compoundHCID 58392410HCID 58392410, compound

Product 1

HCID 58392229HCID 58392229, compound

Procedure

The title compound was prepared starting from 2.20 g (4.62 mmol) of the compound from Example 67A in analogy to the synthesis of the compound from Example 50. 1.66 g (88% of theory) of the target compound were obtained.

Workup

  1. custom1.66 g (88% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-fcb5130f53ec4b20b944736d0b7ff1a4
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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