HCID 58392361, compound → HCID 58392495, compound

HRID 561556Notes

Reaction equation

HRID 561556 reaction equation
CS(O[CH2:6][CH2:7][CH:8]([C:21]1[CH:22]=[CH:23][C:24]2[S:28][CH:27]=[CH:26][C:25]=2[CH:29]=1)[C:9]1[C:17]2[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)(=O)=O.ClC1C=CC(C(C2C3C(=C(CSC)C(F)=CC=3)NC=2)CC[C:40]#[N:41])=CC=1>>[S:28]1[C:24]2[CH:23]=[CH:22][C:21]([CH:8]([C:9]3[C:17]4[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=4)[NH:11][CH:10]=3)[CH2:7][CH2:6][C:40]#[N:41])=[CH:29][C:25]=2[CH:26]=[CH:27]1

Participants

3

Reactant 2

HCID 58392361HCID 58392361, compoundHCID 58392410HCID 58392410, compound

Product 1

HCID 58392495HCID 58392495, compound

Procedure

The title compound was prepared starting from 768 mg (1.72 mmol) of the compound from Example 68A in analogy to the synthesis of the compound from Example 50. 494 mg (76% of theory) of the target compound were obtained.

Workup

  1. custom494 mg (76% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-5020768147a64b0a9ccf737330321176
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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