HCID 58392115, compound → HCID 58392478, compound

HRID 561560Notes

Reaction equation

HRID 561560 reaction equation
[S:1]1C2C=CC(C(C3C4C(=C(CSC)C=CC=4)NC=3)CCC#N)=CC=2[CH:3]=[CH:2]1.F[C:28]1[C:36]([CH2:37][S:38]([CH3:41])(=[O:40])=[O:39])=[C:35]2[C:31]([C:32]([CH:42]([C:47]3[CH:52]=[CH:51][C:50](C(F)(F)F)=[CH:49][CH:48]=3)[CH2:43][CH2:44][C:45]#[N:46])=[CH:33][NH:34]2)=[CH:30][CH:29]=1>>[S:1]1[C:50]2[CH:51]=[CH:52][C:47]([CH:42]([C:32]3[C:31]4[C:35](=[C:36]([CH2:37][S:38]([CH3:41])(=[O:40])=[O:39])[CH:28]=[CH:29][CH:30]=4)[NH:34][CH:33]=3)[CH2:43][CH2:44][C:45]#[N:46])=[CH:48][C:49]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 58392115HCID 58392115, compoundHCID 58392495HCID 58392495, compound

Product 1

HCID 58392478HCID 58392478, compound

Procedure

The title compound was prepared starting from 284 mg (0.75 mmol) of the compound from Example 52 in analogy to the synthesis of the compound from Example 72. 409 mg (54% of theory) of the target compound were obtained.

Workup

  1. custom409 mg (54% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-3ccdf6972cf64aa6a89e637b1080c9e1
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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