HCID 58392229, compound → HCID 58392497, compound

HRID 561572Notes

Reaction equation

HRID 561572 reaction equation
[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([C:6]([CH:14]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[CH2:15][CH2:16][C:17]#[N:18])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.ClC1C=CC(C(C2C3C(=C(CS(C)=[O:53])C(F)=CC=3)NC=2)CCC#N)=CC=1>>[F:1][C:2]1[C:10]([CH2:11][S:12]([CH3:13])=[O:53])=[C:9]2[C:5]([C:6]([CH:14]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([F:28])([F:26])[F:27])=[CH:23][CH:24]=3)[CH2:15][CH2:16][C:17]#[N:18])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58392229HCID 58392229, compoundHCID 58392451HCID 58392451, compound

Product 1

HCID 58392497HCID 58392497, compound

Procedure

The title compound was prepared starting from 557 mg (1.37 mmol) of the compound from Example 51 in analogy to the synthesis of the compound from Example 88. 412 mg (71% of theory) of the target compound were obtained as mixture of diastereomers.

Workup

  1. custom412 mg (71% of theory) of the target compound were obtained as mixture of diastereomers

Sources & evidence

ORD record
ord-e1332f70c8434b2eb6c56fe9a47d150d
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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